If you guys have not use this combination I strongly suggest to give it a try. Prism handles navigation like a boss, ReactiveUI makes your code readable that you will comeback 6 months from today and you will still be able to pick it up fairly quickly (that is not the only reason of course but one of the most appealing for me) and Xamarin Forms (no need for introductions here).
If you have never used Prism or ReactiveUI I recommend:
Prism in Xamarin Forms Step by Step by Xamgirl.
And
You, I, and ReactiveUI by Kent Boogaart.
Now, How do we use them together?